Cardiac arrhythmias such as ventricular tachycardias and fibrillation are also a hallmark of the pathogenic PLN mutation R14del (Haghighi et al., 2006; Posch et al., 2009; van Rijsingen et al., 2012; Hof et al., 2019). The gene discussed is PLN; the disease is chronic obstructive pulmonary disease.