Since cardiac arrhythmias are a major issue for patients with the PLN mutation R14del (Haghighi et al., 2006; Posch et al., 2009; van Rijsingen et al., 2012; Hof et al., 2019), we wanted to know whether noise filtering is impaired if we implement the known molecular effects of this mutation into our model. This evidence concerns the gene PLN and chronic obstructive pulmonary disease.