Multiple mutations in the PLN gene have been discovered in the past two decades, most of which cause severe forms of cardiomyopathy and lead to cardiac arrhythmias or heart failure (Schmitt et al., 2003, 2009; Haghighi et al., 2006; Medeiros et al., 2011; Yost et al., 2019). The gene discussed is PLN; the disease is cardiac rhythm disease.