PLN and cardiac arrhythmia: Since cardiac arrhythmias are a major issue for patients with the PLN mutation R14del (Haghighi et al., 2006; Posch et al., 2009; van Rijsingen et al., 2012; Hof et al., 2019), we wanted to know whether noise filtering is impaired if we implement the known molecular effects of this mutation into our model.