Molecular mechanisms linking NOX5 to downstream signalling elements in hypertension involve multiple systems, but c-Src may be especially important because (i) it acts as a signalling hub in VSMCs,43 (ii) it is tightly regulated by vasoactive and pro-HT factors, including Ang II,44,45 and (iii) c-Src polymorphisms have been associated with hypertension.14 This evidence concerns the gene NOX5 and Hypertension.