483 Lachin Lachin JM JM Genuth Genuth S S Cleary Cleary P P Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive insulin therapy Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive insulin therapy N Engl J Med N Engl J Med 2000 2000 342 342 6 6 381 381 389 389 10666428 10666428 483. This evidence concerns the gene INS and type 1 diabetes mellitus.