MRC1 and scrub typhus: Concurrently, a significant reduction in type 2- or tissue healing-related genes, including Cxcl12 (p < 0.05), Ccrl1 (p < 0.0001), Mrc-1 (p < 0.0001), and Ahr (p < 0.0001), provided additional evidence for skewed type 1, but absent type 2, immune responses in our model of severe scrub typhus (Fig 5C).