More specifically, RSV-A2 and RSV-ON1-H1 infection induced a significant upregulation of retinoic acid-inducible gene-I (RIG-I), melanoma differentiation-associated protein 5 (MDA-5), 2’,5’-oligoadenylate synthetase 2 (2’,5’-OAS), interferon (IFN)-induced dynamin-like GTPase (MxA), and virus inhibitory protein, endoplasmic reticulum-associated, IFN-inducible (Viperin) compared to mock control (Fig 2A). The gene discussed is IFIH1; the disease is infection.