To further explore the anticancer effects of C-IN2 in ITGB1 positive gastric tumor tissues, we established subcutaneous gastric tumor bearing mice model by injecting 3D collagen cultured ITGB1 positive SGC-7901 cells into NOD-SCID mice, then mice were treated mice with PBS, 5-FU monotherapy or combining with C-IN2. This evidence concerns the gene ITGB1 and gastric neoplasm.