From the first to third tertile, age, diabetes duration, systolic blood pressure (SBP), HbA1c level, total protein concentration, globulin level, UA level, cystatin C level, UACR, percentage of DKD, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, fibrinogen (Fg) level, and D-dimer level significantly increased (P for trend < 0.05), whereas the percentage of females, percentage of patients using insulin, and eGFR decreased (P for trend > 0.05). This evidence concerns the gene INS and diabetes mellitus.