RIGI and infection: Likewise, on day 2 following infection, proteomic analysis revealed an increase in IFN-γ- and TNF-α-stimulated proteins (Fig. 3), and transcriptomic analysis showed elevation of numerous proteins known to be induced by TNF-α as well as other molecules (CXCL10, CCRL2, CCL5, CD274, DDX-58, OAS2, TNFaip3, and XDH), correlating with viral transcript expression.