LncRNAs have been proposed to act as scaffolds that coordinate distinct chromatin‐modifying complexes to target DNA loci.[27] For example, lncBRM interacted with BRM (the ATPase subunit of SWI/SNF complex) to activate YAP1 signaling and promote self‐renewal of liver cancer stem cells, and the binding fragment was predicted to form stable stem‐loop structure.[28] The binding fragments of SCDAL and SNF5 are predicted to harbor stable stem‐loop structures which may facilitate the binding of SNF5 to the promoter of GDF6. This evidence concerns the gene GDF6 and liver cancer.