MAPT and Alzheimer disease: A range of earlier studies has carried out investigations into amyloidogenic tau pathology in AD cortical tissue (indicated by senile plaques, neuritic plaques or NFT’s), finding this to be observed with a predominance for cortical layer 3 and 5 (24, 25, 26, 27, 54) and highlighting preferential deposition and disruption in cortico‐corticol connective regions.