The AD and AR forms, for example, can be linked to the LMNA gene encoding for lamin A and C (EDMD2 and EDMD3) as well as to the SYNE1 and SYNE2 genes encoding nespirin 1 (EDMD4) and 2 (EDMD5), respectively [47]. The gene discussed is SYNE2; the disease is Alzheimer disease.