SNCA and multiple system atrophy: According to the 2008 recommendations for the post-mortem neuropathological diagnosis of MSA “a definite neuropathological diagnosis of MSA is established when there is evidence of widespread and abundant CNS alpha-synuclein-positive GCIs in association with neurodegenerative changes in striatonigral or olivopontocerebellar structures” (Trojanowski and Revesz 2007).