SNCA and multiple system atrophy: The relocation of phosphoprotein-25α (p25α) from myelin to glial cytoplasm and nucleus, which is thought to be an early event in MSA, seems to promote α-synuclein aggregation and misfolding thus enhancing the deposition of GCIs (Song et al. 2007; Ota et al. 2014; Mavroeidi et al. 2019).