The Braak&Braak staging system well reproduces the progression of α-synuclein accumulation and related neurodegeneration in LB-related disorders (Braak et al. 2003) but fails in explaining the clinical and neuropathological progression of MSA, which is a primary oligodendroglioneural pathology (Jellinger 2018a). The gene discussed is SNCA; the disease is multiple system atrophy.