Consistent with their purported role in the etiology of NSCLC, recent studies have shown that β3-αC ΔELREA, L858R, A763-Y764insFQEA, and D770-N771insNPG mutated EGFR proteins are oncogenic in both cell cultures and transgenic mouse models (Ji et al., 2006; Politi et al., 2006; Sordella et al., 2004; Xu et al., 2007; Yasuda et al., 2013). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.