Here, we have presented the effect of four such mutations, namely the L858R, D770-N771insNPG, ΔELREA, and A763-Y764insFQEA, all of which have been shown to increase the catalytic activity of EGFR in vitro (Zhang et al., 2006; Foster et al., 2016; Yasuda et al., 2013) and continuously signal the pathway, which stimulates cancer cell growth. This evidence concerns the gene EGFR and cancer.