First, the canonical pathway analysis of distinct host pathways affected by wild-type Y. pseudotuberculosis infection compared to uninfected cells revealed that proteins affected by infection include such pathways as Cdc42 signaling, ferroptosis signaling pathway, phagosome maturation, Fc-gamma receptor-mediated phagocytosis in macrophages and monocytes, and other functions (Fig. 3D). This evidence concerns the gene CDC42 and infection.