The study of Yu et al., (2016) involving p16/Ki-67 co-expression showed a strong association with CIN 2 + lesion (HR-HPV persistence, especially with HPV16/18) for which p16/Ki-67 could be considered as a suitable biomarker for cervical cancer screening. This evidence concerns the gene CDKN2A and cervical squamous intraepithelial neoplasia.