More than 300 validated polymorphisms in the human XRCC1 gene are listed in the dbSNP database, of which, the most extensively studied SNPs are Arg399Gln (exon 10), Arg280His (exon 9) and Arg194Trp (exon 6) polymorphisms in different cancer (Li et al., 2012, Li et al., 2013; Qi et al., 2014). This evidence concerns the gene XRCC1 and cancer.