The result was consistent with the previous studies showing that inhibition of nucleolin with antisense oligodeoxynucleotides promoted apoptosis in nasopharyngeal cancer (Wu et al., 2012), and Dox could provoke cell apoptosis via caspase-3 activation in breast cancer (Pilco-Ferreto and Calaf, 2016). This evidence concerns the gene CASP3 and breast carcinoma.