For example, Zhu et al. (2012) demonstrated that transfection of CLL cells with miRNA-34, miRNA-181a/b, miRNA-15a and miRNA-16-1 inhibits the expression of Mcl-1 and Bcl-2 and sensitize the CLL cells to fludarabine-induced killing. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.