The aim of the current study was to investigate the effect of 5-aza-CdR in comparison to SAHA on DNMT1, DNMT3a and DNMT3b, HDAC 1-3, SOCS 1, SOCS 3, JAK2, and STAT3 gene expression, cell growth inhibition, and apoptosis induction of HCC HLE and LCL-PI 11 cell lines. This evidence concerns the gene DNMT1 and hepatocellular carcinoma.