CISH and Insulin resistance: Indeed, hepatocyte specific deletion of IQGAP1 scaffolding protein, which enables IR and IRS‐1 to interact, induces insulin resistance and glucose intolerance in vivo.[22] Second, S/T phosphorylations on IRS1 also promote its ubiquitin dependent proteasomal degradation.[21] Hyperactivated mTORC1 signaling also contributes to insulin resistance by phosphorylating and stabilizing Grb10 adaptor protein, which impairs IR‐IRS1 interaction.[23, 24, 25] Similarly, suppression of cytokine signaling (SOCS) scaffolding proteins impair the IR‐IRS‐1 interaction and promote degradation of IRS‐1.[26]