In type 2 diabetes, reduction in insulin's ability to stimulate glucose uptake from peripheral tissues occurs due to the disruption of GLUT4 translocation to the cell surface.[45] Muscle GLUT4 emerges as a specific target upon insulin action because exercise‐modulated GLUT4 translocation remains unchanged in type 2 diabetes.[44] Since exercise—induced glucose uptake remains preserved in insulin resistant—skeletal muscle, exercise is suggested as a key therapy against metabolic diseases such as type 2 diabetes. Here, INS is linked to metabolic disease.