MG modification of ligand‐gated ion channel transient receptor potential cation channel, subfamily A, member 1 (TRPA1) also increases pain related hypersensitivity in diabetic neuropathy (Figure 9).[200] The neuronal oxidative/nitrosative stress also activates MAPK, JNK and nuclear factor “kappa‐light‐chain‐enhancer” of activated B‐cells (NFĸB) pathways that further promote cytokine production and inflammation contributing to diabetic neuropathy. This evidence concerns the gene TRPA1 and diabetic neuropathy.