MG modification of ligand‐gated ion channel transient receptor potential cation channel, subfamily A, member 1 (TRPA1) also increases pain related hypersensitivity in diabetic neuropathy (Figure 9).[200] The neuronal oxidative/nitrosative stress also activates MAPK, JNK and nuclear factor “kappa‐light‐chain‐enhancer” of activated B‐cells (NFĸB) pathways that further promote cytokine production and inflammation contributing to diabetic neuropathy. The gene discussed is MAPK8; the disease is diabetic neuropathy.