Glo1 knockout flies have elevated levels of MG, which induces type 2 diabetes like phenotype such as insulin resistance, obesity, and hyperglycemia.[122] Similarly, Glo1 knockout together with diet‐induced obesity elevates MG levels and induces type 2 diabetes like symptoms in zebrafish.[123] In support of these findings, MG is also sufficient to induce retinopathy like lesions in rat models without inducing hyperglycemia,[124] suggesting that accumulation of MG is creating a shortcut to develop diabetes‐like phenotype in the absence of hyperglycemia. This evidence concerns the gene GLO1 and type 2 diabetes mellitus.