JAML and diabetic kidney disease: Excessive lipid accumulation in the kidney and the accompanying lipotoxicity are unfolding as relatively new concepts that play a role in development of diabetic kidney disease as well.[153] Diabetic mice for instance overexpress junctional adhesion molecule‐like protein (JAML) in their podocytes that activates the Sirtuin‐1 (SIRT1) mediated Srebp1 signaling leading to excessive lipid accumulation and renal lipotoxicity.