RRM2 is a ribonucleotide reductase component that synthesizes deoxyribonucleotides required for mitochondrial and nuclear DNA repair and replication.[32] RRM2 is considered an oncogenic protein that is upregulated in various types of cancer.[33] In this study, we have systemically investigated the tumor‐promoting roles of RRM2 in RCC. This evidence concerns the gene RRM2 and renal cell carcinoma.