As the results shown by multiple detection methods, knockdown of BRG1 significantly prevented the progression of UUO-induced renal fibrosis (Figure 2), more impressively, overexpression of BRG1 without any other interventions after UNx activated fibrotic response directly, as demonstrated by the up-regulated expression of fibronectin, collagen I, and α-SMA in the original healthy kidney (Figure 4). This evidence concerns the gene SMARCA4 and renal fibrosis.