SMARCA4 and renal fibrosis: To establish the causative link between BRG1-induced cellular senescence and renal fibrosis, mice undergoing UNx were subjected to BRG1 overexpression through intravenous injection of BRG1 expression vector (pReceiver-M14-BRG1) or empty vector (pReceiver-M14) for 4 weeks to induce tubular senescence and fibrotic response.