Compared with the unconverted CD44-/CD24- tumor cells, PPME1, RHBDL2 and HIST1H4H mRNA transcripts increased in the newly converted CD44+/CD24- CSCs with a change of >two folds, which were similar to that in parental CD44+/CD24- CSCs (Figure 6D). The gene discussed is RHBDL2; the disease is neoplasm.