Furthermore, up-regulated RHBDL2 expression is associated with worse prognosis of several types of malignant tumors, such as breast cancer, pancreatic adenocarcinoma, clear cell kidney cancer, and low-grade glioma patient (Canzoneri et al., 2014; Johnson et al., 2017). The gene discussed is RHBDL2; the disease is pancreatic adenocarcinoma.