Although the functional consequence of cleaving these substrates has not been fully explored the available findings indicate that RHBDL2 functionally activates the EGF signaling, cadherin shedding, angiogenesis and promotes the wound healing and migration of different types of cells, including tumor cells (Adrain et al., 2011; Cheng et al., 2011). Here, RHBDL2 is linked to neoplasm.