Furthermore, Kaplan-Meier analysis and log-rank test indicated that higher levels of HIST1H4H, RHBDL2, DSCC1, ARL6IP1, PPME1, and lower levels of G2E3 and MED22 mRNA transcripts, but not others, were significantly associated with worse DFS in breast cancer patients in the Cancer Genome Atlas (TCGA) database (Figure 6C). This evidence concerns the gene PPME1 and breast cancer.