The heritability of scoliosis is not likely explained solely by variants in the ADGRG6 locus as most variants only explain between 1 and 2% of heritability given the published odd ratios each variant (Kou et al., 2019; Kou et al., 2013; Kou et al., 2018; Xu et al., 2019). Here, ADGRG6 is linked to scoliosis.