COL2A1 and scoliosis: Despite wedging of IVDs close to the apex of the curvature in Col2a1-Cre; Adgrg6f/f mice, no apparent defects in the size or patterning of the vertebrae, growth plates, or IVD tissues were observed during the initiation of scoliosis at P20 (Figure 3—figure supplement 1A, B), nor prior to the onset of scoliosis at P10 (Figure 3—figure supplement 1E–F’’).