Moreover, patients diagnosed with connective tissue disorders such as Marfan’s syndrome commonly display scoliosis (Glard et al., 2008) and rare variants in the Marfan’s associated fibrillin genes FBN1/2 are associated with AIS in humans (Buchan et al., 2014; Sheng et al., 2019). The gene discussed is FBN1; the disease is connective tissue disorder.