Altogether, this suggested that loss of Adgrg6 in committed cartilages of the axial skeletal is sufficient to generate a mild susceptibility to scoliosis, although with a much lower penetrance compared with removal of Adgrg6 in the whole spine (i.e., Col2a1-Cre; Adgrg6f/f) (Figure 2L). Here, COL2A1 is linked to scoliosis.