A state of enhanced autoimmunity to self‐proteins like the Nf isoforms light (Nf‐L), medium (Nf‐M), and heavy (Nf‐H) but also to dipeptide repeats (DPR), the product of translation of the mutated C9orf72 gene, may therefore result from a changing self‐tolerance environment in ALS. This evidence concerns the gene NFASC and amyotrophic lateral sclerosis.