Univariate predictors associated with decreased survival (p < 0.05) included older age, increased comorbidities, nonviral hepatitis, higher Child–Pugh score, advanced BCLC stage, advanced AJCC stage, increased tumor size, multifocal tumors, bilobar tumor burden, vascular invasion, and extrahepatic metastases as well as systemic therapy and increased alpha‐fetoprotein (AFP). The gene discussed is AFP; the disease is Hepatitis.