It is documented that members of the Bcl‐2 family, including Bcl‐2 and Mcl‐1, regulate apoptosis and caspase activation by regulating the mitochondrial membrane integrity,55 and the decline of the expression levels of Bcl‐2 members contributes to apoptosis induced by some anti‐cancer agents.56, 57. This evidence concerns the gene BCL2 and cancer.