One such all‐in‐one lentiviral vector targeting DNA methylation in SNCA intron 1 was designed by fusing CRISPR‐deactivated Cas9 (dCas9) with the catalytic domain of DNA‐methyltransferase 3A (DNMT3A) has been applied to human induced pluripotent stem cell (hiPSC)‐derived dopaminergic neurons from a PD patient with the SNCA triplication, which successfully resulted in downregulation of SNCA mRNA and protein [142]. Here, SNCA is linked to Parkinson disease.