As it has been reported that α‐synuclein sequesters DNMT1 from the nucleus into the cytoplasm in neurons, likely inducing loss of DNMT1 nuclear function [60], and it has also been shown that the reduction of TET2 in neurons could be neuroprotective in PD [80], these two DNA methylation machinery enzymes may be good therapeutic targets for neurodegeneration. Here, TET2 is linked to Parkinson disease.