The following antibodies and titers are considered laboratory criteria for APS diagnosis: i) positive LAC; ii) IgG or IgM aCL at medium or high titer (>40 GPL/MPL or >99th percentile); iii) IgG or IgM aβ2GP1 at medium or high titer (>99th percentile). The gene discussed is LCT; the disease is autoimmune polyendocrinopathy.