Considering that the inflammatory process is important for endometrial receptivity and embryo implantation50, 51, 52and that chemerin plays a direct role in the establishment of pregnancy,49it is questioned whether the mutation of theCMKLR1gene could be related to the impairment of those important events in women with endometriosis, being able to participate in the etiopathogenesis of disease-related infertility. This evidence concerns the gene RARRES2 and endometriosis.