Zheng et al. [128] reported overexpression of HDAC9 in 41 HCC specimens at levels that were inversely correlated with miR-376a, and further demonstrated that HDAC9 directly downregulates miR-376a expression in human HCC Huh7 cells via a mechanism involving site-specific deacetylation of H3K18 in its upstream region. Here, HDAC9 is linked to hepatocellular carcinoma.