APOE and isolated hemihyperplasia: Additional work has also demonstrated that both sex and diversity of human ApoE genotype as expressed in mice affect receptiveness to LTF following IH.9 In 2013, IH was also studied in human subjects with incomplete SCI and was found to elicit increased minute ventilation (ventilatory LTF) for 30 min after acute exposure.10 However, these effects did not potentiate or become more prolonged following daily IH treatment.