Cite this article as: Brady, RD, Bird, S, Sun, M, Yamakawa, GR, Major, BP, Mychasiuk, R, O'Brien, TJ, McDonald, SJ, and Shultz, SR (2021) Activation of the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway of the unfolded protein response following experimental traumatic brain injury, and treatment with a PERK inhibitor. Here, EIF2AK3 is linked to injury.