This effect was not driven by CRISPRi targets alone, since when the analysis was repeated without them, the same enrichment for divergent lncRNAs was observed (P = 0.0038). We could observe an enrichment of CLC2 genes overlapping or within 10 kb distance of the TSS of the CGC genes compared to non-CGC genes (Supplementary Figure S5D), suggesting cancer co-functionalities for CLC and CGC genes. Here, CLC is linked to cancer.