41 genes with DEU were common to conditions where BMI1 or PRP6 had been silenced with 7/41 belonging to genes previously associated with GBM prognosis (APLP2, EIF3B, EIF4G1, HNRNPA2B1, MACF1, DST, TXNRD2; Supplementary Data 9) (83), with translation initiation and mRNA binding being the network enriched for (Figure 4E and Supplementary data 9). This evidence concerns the gene PRPF6 and glioblastoma.