Seven proteins (MYL6, AKAP9, ALDR, HS71A, KHDR1, ROA3, TAGL2) were part of both the BMI1 and RYBP chromatome (Figure 2B), four of which (AKAP9, MYL6, ALDR and TAGL2) were identified as upregulated in IDH-wild type GBM samples versus non-tumour using TCGA datasets (57) (Supplementary Figure S2B). This evidence concerns the gene RYBP and neoplasm.