Importantly, no enrichment for pathways involved in cholesterol metabolism was observed when either CBX8 or RYBP were silenced, and none of the proteins encoded by DEG upon BMI1 silencing and belonging to these pathways were identified in the BMI1 interactome or as being enriched for BMI1 binding in published ChIP-Seq studies in GBM (79). The gene discussed is CBX8; the disease is glioblastoma.