Dysregulated JNK pathway upon BMI1 knock-down has been previously shown in GSC and NPC (79) and in chronic myeloid leukaemia (CML) cell lines, where it led to upregulation of CCNG2, a G2 cyclin, which in turn increased phosphorylation of phosphate pathways, including the JNK pathway (80), raising the possibility that members of the metalloproteases signalling cascade could be regulated by ncPRC1 and JNK pathway in GBM. This evidence concerns the gene MAPK8 and glioblastoma.