Kataegis has been associated with promiscuous activities of the ‘activation-induced cytidine deaminase’ (AID), ‘apolipoprotein B mRNA editing enzymes, catalytic polypeptide-like’ (APOBEC) and genomic rearrangements in B cell lymphomas (37) and other tumors (38,39). This evidence concerns the gene AICDA and B-cell non-Hodgkin lymphoma.