It also showed intense activity of AID (AICDA), APOBEC3A, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H within CYT-high COAD, and of APOBEC3A, APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H in CYT-high READ (Figure 2C and D), suggesting that inflammation within cytolytic high colorectal tumors switches on the intense activity of various APOBEC genes. The gene discussed is APOBEC3F; the disease is colorectal neoplasm.