It also showed intense activity of AID (AICDA), APOBEC3A, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H within CYT-high COAD, and of APOBEC3A, APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H in CYT-high READ (Figure 2C and D), suggesting that inflammation within cytolytic high colorectal tumors switches on the intense activity of various APOBEC genes. This evidence concerns the gene APOBEC3D and colorectal neoplasm.