Of note, a recent study showed that PVT1 lncRNA expression was not required to inhibit MYC transcription; instead, the PVT1 promoter competed with MYC for enhancer binding at the PVT1 locus, preventing MYC promoter firing and suppressing transcriptional elongation of the MYC oncogene and reducing cancer cell growth (121). The gene discussed is PVT1; the disease is cancer.