Furthermore, TUG1 maintained glioma stem cells through interactions with polycomb repressive protein 2 (PRC2) components (EZH2 and SUZ12 (SUZ12 polycomb repressive complex 2 subunit)) and transcription factor YY1 (Yin and Yang 1 protein), thereby epigenetically suppressing multiple neuronal differentiation-associated genes (87). This evidence concerns the gene EZH2 and central nervous system cancer.