Specifically, synthesis of a large pool of ribosomes that remain unmethylated at SSU-C1440 may allow increased levels of eIF4B in DLBCL to bind more ribosomes and favor translation of mRNAs with highly structured 5′ UTRs such as DAXX, BCL2 and ERCC5 that are involved in tumorigenesis and chemoresistance (48). This evidence concerns the gene EIF4B and diffuse large B-cell lymphoma.