VEGFA gene participates in six pathways (‘VEGF signaling pathway’, ‘Ras signaling pathway’, ‘Rap1 signaling pathway’, ‘HIF-1 signaling pathway’, ‘PI3K–Akt signaling pathway’ and ‘Focal adhesion pathway’) and is part of 81 circuits, 39 of them directly related to cancer hallmarks (18 to ‘Resisting cell death’, 9 to ‘Sustaining proliferative signaling’, 4 to ‘Genome instability and mutation’, 3 to ‘Evading growth suppressors’, 2 to ‘Enabling replicative immortality’, 2 to ‘Inducing angiogenesis’ and 1 to ‘Deregulation of cellular energetics’). The gene discussed is AKT1; the disease is cancer.