On the other hand, the variant named 501Y.V2 (also known as B.1.351, characterized by substitutions in two immunodominant domains of the spike protein) dominated the infections of the second wave in South Africa and it was effectively neutralized by plasma from individuals who were infected during the second wave but only poorly cross-neutralized by plasma from individuals with first-wave infections (Cele et al., 2021; Wibmer et al., 2021). The gene discussed is CHMP5; the disease is infection.