CYP1A1 and heart disorder: The rs4646903 mutation of the CYP1A1 gene (T>C) that happen at the downstream polyadenylation site at the 3'UTR non-coding section leads to an increase in the half-life of the mRNA, which is characterized by an increase in the concentration and enzymatic activity of CYP1A1 [19, 20], which in turn can increase the CYP1A1 metabolite level and increased risk of heart disease.