In the tumour suppressor gene category, the first cluster (Table 1) included 29 genes (BHLHE41, CYLD, CDKN2A, FOXO3, NPM1, TCF3, CDX2, CEBPA, RB1, CTCF, NFKB1, WT1, ETV6, NBN, IKZF1, PAX4, PAX5, RUNX1, EZH2, PLK1, CREBBP, NOTCH1, TP53, STAT3, DNMT1, DNMT3A, DNMT3B, FBXW7 and VEGFA) that were annotated with GO biological processes “regulation of nucleobase-containing compound metabolic process” (GO:0045934, p-value = 2.152E−19) and “regulation of nitrogen compound metabolic process” (GO:0051172, p-value = 2.144E−18). The gene discussed is CYLD; the disease is neoplasm.