As for the joint expression of ERCC6/ ERCC8, double positivity was related to small tumor size (P = 0.005), Borrmman I-II stage (P < 0.001), TNM I-II stage (P = 0.001) (P < 0.001 for T stage), Lauren intestinal type (P = 0.014) of GC and negative perineural invasion (P = 0.015). The gene discussed is ERCC6; the disease is gastric cancer.