HLA-DR expression is decreased in all monocyte subsets upon IL-10 exposure in vitro and during septic shock (Monneret et al., 2004; Lee et al., 2017), whereas monocytes that have diminished or no HLA-DR expression, called CD14+HLA-DRlo∕neg monocytes, have emerged as important mediators of tumor-induced immunosuppression (Mengos, Gastineau & Gustafson, 2019). Here, CD14 is linked to neoplasm.