Interestingly, significant increase (p < 0.001) in expressions of PI3K, phospho-JNK (pJNK), phospho-AKT (pAKT) and phospho-JunD (pJunD) were observed in the tumor tissues compared to normal tissues (Figure 5C; Supplementary Figure 7A). The gene discussed is AKT1; the disease is neoplasm.