Based on a single report describing the role of JunD in regulating intestinal epithelial barrier function [41] and since pJunD was elevated in tumor samples, we checked the status of JunD phosphorylation in HEp-2 cells in addition to various components of the MAP kinase signaling pathway, such as PI3K, JNK and AKT. Here, MAPK8 is linked to neoplasm.