INS and neoplasm: For example, miR-30a has been associated as a tumor suppressor in HNSCC [38], high let-7d influences HNSCC growth [39], miR-3913 and miR-6892 have been associated with immune signature and candidate prognostic marker in HNSCC [40], miR-181d is shown to be predictive of risk in HNSCC [41], miR-141 suppresses growth and metastatic potential [42]; miR-370 has been shown to regulate insulin sensitivity and modulate tumor growth [43], miR-378 [44], miR-1910 and miR-187 are shown to be induced in HNSCC [10, 45].