TGFB1 and cancer: Pathway analysis of the two miRNAs hsa-mir-10a-5p, hsa-miR-194-5p that was consistently shown by random forest to be significantly associated with LVI and also identified as positively regulated with LVI in Wilma cluster 1 were found to be involved in regulation of several important cancer associated pathways such as Hippo signaling, adherens junction, fatty acid metabolism, circadian rhythm, TGF-β and p53 signaling pathways (Table 4).