The combination of SFN and AZ reduced the pro-survival PI3K/Akt/mTOR pathway, upended pro-survival hypoxia-mediated pathways resulting in decreased 5-HT secretion, migration of H727 and H720 cells in xenografts, and targeted the pro-survival Keap1/Nrf2 pathway, with an overall marked induction of BC cell apoptosis. The gene discussed is AKT1; the disease is breast cancer.