In Figure 9, we summarize the observations of AZ, SFN, and the combination of AZ and SFN effects in BC, demonstrating how the simultaneous multi-targeting of key pro-survival pathways (hypoxia, antioxidant, and PI3K/Akt/mTOR) and pH homeostasis could represent a promising therapeutic regimen for BC. The gene discussed is AKT1; the disease is breast cancer.