The combination of SFN and AZ reduced migration of BC in a scratch wound, upended pro-survival hypoxia-mediated pathways resulting in decreased 5-HT secretion, upended the pro-survival PI3K/Akt/mTOR pathway of BC xenografts of H727 and H720 cells, targeted the pro-survival Keap1/Nrf2 pathway, and induced bronchial carcinoid cell apoptosis. The gene discussed is KEAP1; the disease is breast cancer.