Several chemokines, chemokine ligands, cytokines, matrix metallopeptidases (MMPs), integrin and genes of lymphocyte migrations were upregulated in BA patients as compared to WA, including CXCL10, CXCL2, HLA-A, CCL2, CCL21, CCL3, CCR4, CCR5, CD4, ITGA4, ITGB2, ICAM1, ICAM2, CD86, and CTLA4 (Figure 2D, Supplementary Dataset 2; Supplementary Table 2A). Here, CCR4 is linked to breast angiosarcoma.