Several genes of antiviral immune response pathways such as HLA-B, HLA-C, HLA-DQB1 IFI6, IFITM3, CD74, and tumor suppressor genes EFEMP1 and EGR1, are upregulated in tumor and downregulated in TAS (Figure 3B, Supplementary Figure 5). The gene discussed is IFITM3; the disease is neoplasm.