Taken together, these results indicate that E2F2 is essential for B-Myb-mediated activation of ERK and AKT signaling pathways in CRC cells, and also suggest that B-Myb may mediate activation of ERK and AKT pathways at least through upregulation of IGFBP3 in CRC cells. Here, AKT1 is linked to colorectal carcinoma.