E2F1 and cancer: Moreover, gene set enrichment analysis (GSEA) analysis using Molecular Signature Database gene sets yielded several cancer-related gene sets, including E2F1-activated gene signatures (E2F1_UP.V1_UP), serum-stimulated gene signatures (CSR_LATE_UP.V1_UP), MYC-activated gene signatures (MYC_UP.V1_UP), etc (Fig. 5d, e and Supplementary Fig. 2).