In contrast, previous studies showed that L-748706, a selective cyclooxygenase-2 inhibitor, displayed protective effects of ESCC development and progression in low-dose (0.25 mg/kg for 5 weeks) NMBzA-treated rats, but insufficiently protected ESCC development and progression in high-dose (0.5 mg/kg for 5 weeks) NMBzA-treated rats [63]. Here, PTGS2 is linked to esophageal squamous cell carcinoma.